ABSTRACT
Purpose To investigate the clinical-pathological characteristics of the primary thyroid intravascular large B-cell lymphoma (PT-IVLBCL). Methods The clinical-patho-logical data of the PT-IVLBCL were analyzed retrospective. A comprehensive analysis of the literature on IVLBCL published between 1991-2017 in China were performed. Results A thy-roid mass was identified in a physical examination of a 68-year-old male who initially presented with dyspnea accompanied by intermittent headache for about 1 month. Pathological results showed that large atypical lymphoma-like cells filled the small vessel capillaries in the lesion area. Immunohistochemical staining revealed that the lymphoma-like cells were positive for CD20, Pax-5, BCL-2 and MUM1. The Ki-67 index was estimated to be approximately 85％. Conclusion IVLBCL is a rare and aggressive disease that is easy to be misdiagnosed or missed, because it's clinical presentations are non-specific. The correct diagnosis depends on pathology. IVLBCL is known for its rapid progression and poor prognosis, but timely diagnosis and treatment with chemotherapy can improve patients survival.
ABSTRACT
Age-related maculadegeneration (AMD) ione of majoretinal diseaseleading to central vision loss.Apresent,the pathogenesiof AMD ibelow understood.Ovethe pasdecade years,dysmetabolism of extracellulamatrix (ECM) regulated by matrix metalloproteinase(MMPs) and tissue inhibitoof metalloproteinase(TIMPs) system play an importanrole in the pathogenesiof AMD.The imbalance of MMPand TIMPleadto differenpathological changeof Bruch 'membrane,which involvein drusen formation and regulatechoroidal neovascularization (CNV).The level of elastin-derived peptides(EDPs) reflectthe level and activity of M MPs,and the elevated level of EDPincreasethe risk of early AMD to advance neovasculaAMD.Thiarticle reviewthe research progression of MMPs,TIMPand the elastin-derived peptideand in AMD.
ABSTRACT
The radial support capacity of intravascular stent is usually evaluated by the planar compression or the radial compression methods. Based on FEM simulation, the planer and radial compression methods are compared, and the agreement of the evaluation for the radial support capacity between these two methods is found. Moreover, the planer compression method is used to study the geometric parameters' effect on the radial support capacity by numerical simulations and experiments. Results show that, at the beginning of the compression process, the radial support capacity is mainly influenced by the metal-to-artery surface ratio; at large compression rate, the radial support capacity will decrease sharply with the increment of post-expansion diameter and decrement of the thickness and metal-to-artery surface ratio. The results provide guidance to the design and test of stents.
Subject(s)
Computer Simulation , Models, Cardiovascular , Prosthesis Design , Software , StentsABSTRACT
The implantation of intravascular stents has become a new method to cure stenosis in arteries with its low injury and high efficiency. The mechanical behavior of the stents is studied by the finite element method. The compression behavior is simulated with stent models of different sizes and geometry structures whose material is cobalt-chromium alloy. Experiments are also carried out to verify the simulation method, which shows that the finite element model can substitute the stent to some extent in which its mechanical behavior is studied. The results show that the reaction stress of the stent increases with the thickness of the strut. Besides, the smaller metal surface area ratio will result in a smaller elongation ratio. All these are helpful and instructive to the proper designs and actual operation of intravascular stents.